Which disease is associated with lethargy, splenomegaly, lymph node enlargement, and fever?

• A. Mononucleosis
• B. Splenomegaly
• C. Dysarthria
• D. Dysthymia

Answer: (A)

These symptoms point to infectious mononucleosis caused by the Epstein-Barr virus. Fatigue, fever, swollen lymph nodes, and an enlarged spleen form a classic cluster for mono, which often appears in teens and young adults and is commonly spread through saliva. In a typical course, you’d also see sore throat and cervical lymphadenopathy, with the spleen frequently enlarging as the immune system responds. Management is supportive: plenty of fluids, rest, fever/pain control, and important caution with activity because an enlarged spleen raises the risk of rupture—so sports or heavy lifting should be avoided until a clinician confirms it’s safe. The other options don’t fit this symptom combination: a speech articulation issue isn’t described by these signs, a mood disorder doesn’t present with these physical findings, and an enlarged spleen by itself isn’t a disease name.