Which combination of signs is most consistent with thyroid storm?

• A. Fever, Altered Mental Status, Tachycardia, Hypotension
• B. Hypothermia, bradycardia
• C. Weight gain and edema
• D. Hyperglycemia

Answer: (A)

Thyroid storm presents as a dangerous surge in metabolism driven by excess thyroid hormone and sympathetic activity. The hallmark features are high fever, mental status changes, and rapid heart rate, with possible progression to cardiovascular collapse and hypotension. So this combination—fever, altered mental status, tachycardia, and hypotension—best matches the severe hyperthyroid crisis, reflecting both CNS hyperactivity and vascular instability.

Options with hypothermia and bradycardia would suggest different conditions, such as severe hypothyroidism rather than an acute storm. Weight gain and edema point toward hypothyroidism as well, not an acute thyrotoxic crisis. Hyperglycemia can occur in many conditions and doesn’t define thyroid storm.