In sarcoidosis, which combination of organs is commonly affected?

• A. Lungs, brain, and liver
• B. Lungs only
• C. Brain only
• D. Lungs, heart, and brain

Answer: (D)

Sarcoidosis is a multisystem disease that most certainly affects the lungs, with granulomas developing in the lung tissue and nearby lymph nodes. When the disease involves other organs, the heart and the nervous system are two of the key extrapulmonary sites that can be involved alongside the lungs. Cardiac sarcoidosis may cause rhythm problems, conduction disturbances, and heart failure, while neurosarcoidosis can produce a range of neurologic symptoms. Because the lungs are typically involved and the heart and brain are important systems that can be affected in disseminated disease, the combination of lungs, heart, and brain reflects the multisystem nature you should be aware of in sarcoidosis. The other options either omit the heart or the lungs, or pair brain involvement with a less likely accompanying organ, making them less representative of the common patterns seen in this condition.