Crohn's disease can involve which portion of the gastrointestinal tract?

• A. Only the colon
• B. The mouth to the rectum
• C. The stomach only
• D. The esophagus only

Answer: (B)

Crohn's disease can involve any portion of the gastrointestinal tract from the mouth to the rectum. It’s a transmural inflammatory condition that isn’t limited to one segment, so affected areas can range from the mouth and esophagus through the stomach, small intestine (often the terminal ileum), and colon. Because of this versatility, the description that opts for involvement spanning from the mouth to the rectum best matches how Crohn's can present. The other options wrongly imply the disease is confined to a single area like the colon, stomach, or esophagus, which Crohn's can indeed affect but not exclusively.